The synthesis and degradation of articular cartilage is delicately balanced and mediated by chondrocytes
Proteoglycan turnover is estimated to take up to 25 years, while collagen half-life is estimated to range from several decades to 400 years [9,13].
Therefore, damages to the tissue can further play a role in the progression of slow degeneration of the tissue and elevate OA like conditions.
Early diagnosis and treatment of Osteoarthritis (OA) 